نوع مقاله : مقاله علمی - پژوهشی
نویسندگان
1 بیوشیمی، علوم زیستی، دانشگاه آزاد اسلامی واحد تهران شما، تهران، ایران
2 گروه زیست شناسی، دانشکده علوم پایه، دانشگاه آزاد اسلامی واحد یادگار امام (ره)
3 گروه بیوشیمی، دانشکده علوم زیستی، دانشگاه تربیت مدرس، تهران، ایران
4 گروه میکروبیولوژی، دانشکده علوم پایه، دانشگاه آزاد اسلامی واحد کرج
چکیده
کلیدواژهها
موضوعات
عنوان مقاله [English]
نویسندگان [English]
The reduction of pathogenicity due to the biological structure of the virus envelope was targeted in this study. Therefore, considering the effect of the prepared solution (Nardin 19) on enveloped viruses, the aim of this study was to investigate the preventive effects of this solution on SARS co-2 virus and H1N1 flu on Vero cell line cells, respectively. And red blood cells The results of this study showed that nardin 19 solution significantly (P <0.001) reduced 2 logs of SARS Co-2 virus in approximately 2 minutes. Also, the results of hemagglutination test for H1N1 influenza virus showed that this solution was able to reduce the virus titer from 516 units to 2 units of hemagglutination in approximately 2 minutes (P <0.001). The results of cytotoxicity test for Nardin 19 solution showed that this solution had no toxicity or lethal effect on Vero cells and red blood cells in one hour. Considering that one of the main ways of penetration of SARS-2 virus and H1N1 flu is through the mouth and nose and also the significant effectiveness of nardin 19 solution in reducing the concentration of these viruses in approximately 2 minutes, according to this use Nardin 19 solution can be suggested as a suitable candidate for the prevention of Quid 19 and influenza as a mouthwash and nasal drops solution.
کلیدواژهها [English]