Iran is affected by the earthquake at a very high level, and it stands after China, India and Bangladesh. Although an earthquake is not a predictable, developed society can reduce its impacts by appropriate management and programming. So it is important to present a model which is organized and inclusive and can show the relationship between effective factors to reduce unwanted effects. This research used Interpretive Structural Modeling (ISM) to present a model which can explain the relationship between effective factors to control and reduce the damages of an earthquake. In this research, quantitative and qualitative methods were combined to make a model which may help managers in urgent situations to make good decision and prepare suitable programs. In this research Delphi method and Second Order Confirmatory Factors Analysis were employed to detect effective factors in reducing and controlling earthquake damages. After confirming these factors, by Partial Least Square software the opinions of 15 managers of Yazd Red Crescent Community were used to build the main model of the research. The results showed that those proposed factors can evaluate the exceptional concept of the research. According to the prepared model, “factors-related related values”, “managing and strategic factors” and “urbanity factors” are the basis of the model of reducing and controlling damages of the earthquake.