Human resource is the most important tool for the organizational agility and the most valuable asset of any organization. Since the environmental conditions influenced by many factors is constantly changing and evolving, Some of these transformations appear suddenly and turns to the crisis and therefore, the management of the organization must be prepared to manage the formed crisis by using the human resources agility. The purpose of this study is to evaluate the effects of the human resources agility on improving the crisis management of blood transfusion organization. In this study, referring to the scientific literature and research, Theoretical and scientific background was carefully studied and the main components and variables were identified and the questionnaire was prepared and after approval of its content and formal validity, the questionnaire was conducted on all samples In this study the human resources agility includes the components of competence and intelligence, employee empowerment, participation in decision-making, knowledge sharing through technology and processes integration and crisis management includes elements of  risk taking, prevention and reducing Destructive effect, forecasting and early preparation, responsiveness and recovery. The research population is consisted of managers and experts in Isfahan Blood Transfusion Center and 3 accident-prone province with at least 10 years of experience that is 161 people. In this study, the simple random sampling method is used. the SPSS and AMOS softwares are used to analyze data andtest the research hypotheses Based on the obtained results, all components of human resource agility have significant and positive impact on improving crisis management.